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HS induces S-sulfhydration of MuRF1 at the Cys44 site, inhibiting its E3 ligase activity, reducing SERCA2a ubiquitination and degradation, thereby restoring SERCA2a function, lowering intracellular Ca 2+ , and enhancing contractile performance (Peng et al., 2022)

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Nat Rev Immunol 2:725734 Li H-X, Zhao W, Shi Y, Li Y-N, Zhang L-S, Zhang H-Q, Wang D (2015) Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis

Allosteric inhibition of phosphofructokinase-1 by citrate forms the basis of the Pasteur effect, the absence of which is critical for understanding the Warburg effect, i.e., aerobic glycolysis, a general feature of not just tumor cells 99 , but also healthy proliferating cells 100 such as lymphocytes and stem cells 101,102