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However, high doses of vitamin B12, such as those used to treat a deficiency, might cause: Headache Nausea and vomiting Diarrhea Fatigue or weakness Its important to note that these side effects are generally mild and temporary

Cancer 122(6):917-28, 2016

And where does the name come from

Another aspect of barrier function is related to the functioning of multiple active transporters, which carry nutrients and metabolites in both directions (Campos-Bedolla et al., 2014