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Many of the metabolic effects of CR in model organisms are also observed in humans

The first step is to measure cardiovascular risk more accurately, think in cumulative exposure rather than only 10-year horizons, use apoB where possible and especially where standard markers are most likely to underrepresent risk, intervene earlier when trajectory, family history, metabolic phenotype, or imaging suggest that the risk is being understated, and keep treatment burden proportional to the quality of evidence and the person in front of the doctor

Your doctor can discuss these with you when you go over your medically supervised weight-loss plan

Matsumoto T, Kojima M, Takayanagi K, Taguchi K, Kobayashi T (2020) Role of S-Equol, indoxyl sulfate, and trimethylamine N-oxide on vascular function

The skinny shot is generally not covered by insurance because most insurance companies classify it as an elective or cosmetic procedure rather than a medically necessary treatment