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So on average, 1 mg would be down to 0.5 mg after one minute and gone after (about) two minutes

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The structured dose-escalation protocol used in the trial was specifically designed to mitigate gastrointestinal burden, and this approach is likely to inform any future prescribing guidance

Subsequently, the mixture was incubated at 37 C for 15 min, and the absorbance spectrum was recorded across the wavelength range of 350 ~ 750 nm

Journal of Obesity and Metabolic Syndrome