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This ramp-up period helps people adjust to the drug but is also when side effects tend to be most prevalentspecifically the gastrointestinal issues that can complicate some surgeries

Sethuram R, Bai D, Abu-Soud HM

Lin SH, Brown DW, Machiela MJ

52 Although the mechanisms underlying the sex- and compartment-specific skeletal effects of CR remain incompletely defined, several plausible explanations can be advanced

These factors disrupt iron homeostasis by promoting hepcidin expression and inhibiting ferroportin-mediated iron export, thereby increasing intracellular free iron levels