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Approximately 40% of colon cancer patients have KRAS mutations, and patients with KRAS G13D have a poor prognosis, including susceptibility to metastasis and short survival time, while anti-EGFR therapy offers little benefit

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Therefore, it is challenging to observe changes in SREBP without being affected by cholesterol

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5.4 GLP-1s anti-apoptotic effects GLP-1 RAs exhibit strong anti-apoptotic effects by activating the PI3K/Akt pathway, which promotes cell survival by inhibiting pro-apoptotic factors such as Bax and caspase-3, while upregulating anti-apoptotic proteins like Bcl-2 (104106)