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It has previously been shown that IFN- treatment of primary mouse hepatocytes reduced transcript levels of genes involved in glutathione (GSH), amino acid, drug, fatty acid and cofactor metabolism, while upregulating expression of tryptophan 2,3-dioxygenase [1]

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765 , 767 , 773 If the aging of the United States population continues at the current pace, an estimated 32,521 geriatricians will be needed to effectively care for the approximately 22.7 million individuals age 65 and older who are projected to have multiple complex health conditions, including living with Alzheimer's dementia in 2050 more than quadruple the number of geriatricians who were practicing in 2021

B.OrtizR.et al (2023)