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Localised injection near target tissue (a damaged tendon, joint, muscle) is used in musculoskeletal repair research where proximity to the injury site may enhance local angiogenesis and fibroblast activation

Small molecule therapies include upadacitinib (Rinvoq), a JAK inhibitor that blocks intracellular signaling pathways involved in inflammation

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IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

This study aimed to evaluate the effects of different tirzepatide doses (7.5 mg vs