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While significant weight loss becomes more apparent over time as the dosages are scaled up, it is not unusual for patients to notice subtle changes in their bodies during the first week

This term refers to the physical changes in the feet that occur due to rapid and significant weight loss, which is often associated with these medications

Some individuals on GLP-1s may reduce fluid intake because these medications delay gastric emptying, and patients may feel too full to drink more, says Marie Hiett, RD, a registered dietitian at Tufts Medicine Weight + WellnessStoneham in Massachusetts

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In particular dietary resistant starch has been shown in studies to upregulate GLP-1 and PYY (Peptide YY, a hormone that can decrease appetite) in a sustained manner