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In a 2022 study of tirzepatide participants who took a weekly 15 mg dose lost an average of 20.9% of their body weight over 72 weeks, compared with 3.1% in the placebo group

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Additionally, catalpol protects against Triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the protein kinase RNA-like endoplasmic reticulum kinase (PERK)/Activating Transcription Factor 4 (ATF4)/CHOP pathway, reversing liver function indices, autophagy levels, and apoptotic protein expression (Zhang L

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