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Cross-trial comparisons can be misleading because trial designs, populations, doses, timelines, and endpoints differ

Dysfunctional adipose tissue promotes increased cardiovascular and diabetes disease risk via multiple pathways including increased free fatty acids (FFA) in the liver, infiltration of visceral fat deposits by proinflammatory macrophages resulting in chronic low-grade inflammation, and reduced buffering capacity for protective lipid storage [7]

These include: Nausea (most common, particularly at higher doses) Vomiting Diarrhoea Constipation Decreased appetite Gastrointestinal events were generally mild to moderate in severity and tended to resolve as participants adapted to each dose level

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