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How to Minimize Muscle Loss (Three Levers) The reason clinicians emphasize lifestyle alongside these drugs is that lean-mass loss is largely modifiable

One hypothesis for these observed differences is that biological sex influences gut microbial composition through hormone-regulated immune and metabolic pathways, with sex steroid hormones and sex-linked genetic factors shaping the immune environment and selectively supporting the growth of certain microbial taxa (Jaggar et al., 2020)

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Early retrospective studies in PV had suggested a superior median survival with myelosuppressive therapy as opposed to either no treatment (median survival 18 months) or treatment with phlebotomy alone (median survival close to 4 years) [33], while at the same time raised concerns regarding myelosuppressive drug leukemogenecity [34, 35]

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