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Table 1 Therapeutic agents targeting the gut microbiota-ferroptosis axis in OA: mechanisms and evidence

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Some patients find that immune support IV drips help them feel better during the adjustment period

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Its primary mechanism is telomerase activation the upregulation of the enzyme responsible for maintaining the protective caps on chromosomes

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Metal-based nanomaterials, characterized by degeneration in the TME, can be designed for programmed release of payloads in response to physiological stimulation

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It occupies a scientifically legitimate space between those extremes: a peptide with a plausible endogenous origin, a well-characterized set of molecular targets, and an unusually consistent preclinical record across diverse injury models and species

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