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It has been reported that inflammation induced by direct injection of LPS can disrupt BBB and increase vascular permeability, increasing the infiltration of inflammatory mediators, leading to neuroinflammatory response and cognitive dysfunction (61) (Figure 2)
It is an anti-ulcer peptide (9-12), interacting with NO-system (13), and, unlike other peptides, it is particularly stable in gastric juice (14) and is used consistently without a carrier (9-11, 13-24), being safe in patients with the inflammatory bowel disease (coded PL-10, PLD 116, PL 14736) (21)
[11] Pernicious anemia can be treated with injections of vitamin B 12
For instance, it may be difficult or dangerous to remove a severely inflamed gallbladder laparoscopically