vial of semaglutide 99.00 | --- 5 mg / 2 ml --- 2 ml --- Weight Loss Glucagon-Like Peptide-1 (GLP-1) Semaglutide 20mg — 20mg/vial Reference

Nally LM, Sherr JL, Van Name MA, Patel AD, Tamborlane WV (2019) Pharmacologic treatment options for type 1 diabetes: whats new

How the cagrilintide + retatrutide stack compares Feature Components Cagrilintide + Retatrutide Cagrilintide + Retatrutide CagriSema (Cag + Sema) Cagrilintide + Semaglutide Retatrutide Alone Retatrutide only Feature Receptor coverage Cagrilintide + Retatrutide AMY + GLP-1R + GIPR + GCGR CagriSema (Cag + Sema) AMY + GLP-1R Retatrutide Alone GLP-1R + GIPR + GCGR Feature Combination clinical data Cagrilintide + Retatrutide None (speculative) CagriSema (Cag + Sema) Phase 3 REDEFINE-1: ~22.7% at 68 weeks Retatrutide Alone Not a combination

Moisturize to form a protective seal around skin: Avoid creams with retinol

Dose dialing is built in

It has no effect on clotting, bleeding, or anaesthetic metabolism