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Developed by Eli Lilly, retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors a mechanism that may offer advantages for weight management, metabolic health, and conditions such as polycystic ovary syndrome (PCOS) that disproportionately affect women

Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial

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46 Adverse Effects and Tolerability of GLP-1RAs in Clinical Practice Although the cardiovascular benefits of GLP-1RAs are significant, their use is commonly associated with well-characterised adverse effects that can affect tolerability and long-term medication adherence, as detailed below

Structured, small meals are preferable to prolonged fasting