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Intrinsic Factor replacement therapy can cause side effects such as: Pain or swelling at the injection site Allergic reactions to the synthetic intrinsic factor The adverse effects may be transient in some situations and get better with time, but they may also be severe in other circumstances and need medical treatment

This means that it is not possible to overdose on vitamin B12, and as far as we know there is no upper limit on the amount of B12 that can be taken safely by an otherwise healthy person

Very friendly physician called me the first time I ordered