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The delayed gastric emptying caused by semaglutide can increase aspiration risk during anesthesia, so most surgeons recommend discontinuing the medication two to four weeks before scheduled procedures

Due to its high structural similarity, the peptide has been incorporated into mechanistic studies examining melanocortin receptor selectivity, agonist potency, and downstream signaling dynamics

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Mutations of the salt bridge residues E124 3.33 and R283 6.55 to either alanine or glutamine could almost abolish ghrelin binding (Supplementary Fig