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Okun The New England Journal of Medicines recent publication of a randomized study of a GLP-1 agonist originally designed for diabetes, but applied to Parkinson's disease, has led to a flurry of excitement and to a mountain of questions
However, a detailed mechanistic understanding of GLP-1R activation linked to downstream signalling is still lacking, with the existing structural information unable to fully explain how differential peptide efficacies arise, or the differential requirements of the N-terminus and C-terminal sequences of peptide analogues
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Semaglutide (wegovy) is now FDA-approved as a weight loss medication The long-awaited approval of semaglutide 2.4 mg weekly injection for weight loss has been considered a game-changer by obesity experts