surmount-1 tirzepatide weight loss percent nejm 2022 Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity Retatrutide produces up to 30.3%

Frye et al

The less frequent need for injections can mean that users do not develop the same level of comfort or routine, which may influence their overall experience and adherence

Public health advocates contend that this often constitutes cosmetic use, with patients seeking weight reduction without meeting the clinical criteria required to be prescribed the therapy Notably, in 2025 a writ petition was filed in the Delhi High Court seeking to curb the misuse of GLP-1 injectables

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At $349 monthly cash-pay (or $199 for compounded semaglutide), these options cost 65% to 80% less than Mounjaro at retail, though with somewhat lower average weight loss (14.9% versus 22.5%)