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Candidates were defined as therapeutic targets if they were significantly increased in tumors for a given subtype or differentiation state (adjusted P 0.05, Wilcoxon rank-sum with BenjaminiHochberg correction) and had a CRISPR gene effect score significantly below zero ( P 0.05)

Stefano GB, Kream RM (2007) Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution

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