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This approach reframes GLP-1 therapy as one component of comprehensive metabolic and hepatic risk management rather than a surrogate for liver protection

Hepatic SIRT1 knockdown or systemic SIRT1 inactivation exacerbates HFD-induced hepatic steatosis, while SIRT1 overexpression attenuates liver damage and improves metabolic profiles [13,14]

Gao, L., Shi, X

Elective procedures under general anesthesia typically require GLP-1 discontinuation 2 to 4 weeks beforehand due to gastric emptying concerns

Tirzepatide and lipid profile improvements have been particularly promising in overweight individuals with metabolic syndrome