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In a recent meta-analysis, some 30% of children with atopic dermatitis (AD) also have asthma, with a figure of 60% in severe AD ( Other patterns associated with asthma development may occur, one of which is initial AR, starting in childhood or young adulthood, with subsequent development of asthma ( 3.1 Concept of pre-asthma Pre- asthma could be defined as a state in which the subject is experiencing mild, probably intermittent lower airways inflammation/ hypersensitivity which is insufficient to cause symptoms, but which is capable of progression to asthma

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