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A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

5ad) and had no acute or chronic effect on mitochondrial functions in differentiated BAT primary cells, including mitochondrial respiration, proton production rate, proton leak respiration, coupling efficiency, maximal substrate oxidation, cellular respiration, non-mitochondrial and mitochondrial respiration, ATP-linked respiration, glycolysis, glycolytic proton production rate and glycolytic and oxidative phosphorylation-linked ATP production (Extended Data Fig

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Collectively, these approaches outline a framework for data-driven optimization and potential route to de-risk translation of oral peptide therapeutics

GLP-1 and amylin have inhibitory effects on: (4) gastric emptying, (5) glucagon release, and (6) appetite