Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option
However, several studies point to a potential nephroprotective role of this pharmacological group in other populations, induced by different factors: improvement of hyperglycemia, overweight and insulin resistance, systemic and glomerular hypertension, dyslipidemia, sodium retention, inflammation and renal hypoxia.15,16 In our series, renal function remained stable, in line with that reported in other series of KT recipients.810 Therefore, our data appear to confirm the notion that, with appropriate monitoring, GLP-1 RAs are safe drugs regarding graft function
These cells can become cholesterol-filled foam cells, an important feature of developing atherosclerotic plaque
The intensity of these effects varies considerably between individuals , influenced by factors including baseline gastrointestinal function, dietary habits, dose escalation speed, and individual sensitivity to GLP-1 receptor activation
The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) are the best-studied and most commonly used incretins
