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The same active drug may appear under different brand names, with different FDA indications, doses, routes, and insurance rules

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The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined

In studies involving adults with type 2 diabetes, Orforglipron significantly lowered glucose levels and produced up to 16 pounds of weight loss, comparable to results seen with some injectable GLP-1 therapies

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